Enzyme

Download
EC Tree
     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.1
Description:Nicotinamide N-methyltransferase.
Prosite: PDOC00844;
PDB:
PDBScop
2I62 8068209; 8068210; 8068209; 8068210; 8068209; 8068210; 8068209; 8068210;
5YJI 8068209; 8068210; 8068209; 8068210;
5XVK 8068209; 8068210; 8068209; 8068210;
6CHH 8068207; 8068208; 8068207; 8068208; 8068207; 8068208; 8068207; 8068208;
6B1A 8068207; 8068208; 8068207; 8068208; 8068207; 8068208; 8068207; 8068208;
 » show all

Cath: 3.40.50.150;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.1
BRENDA Enzyme Link: BRENDA 2.1.1.1
KEGG Enzyme Link: KEGG2.1.1.1
BioCyc Enzyme Link: BioCyc 2.1.1.1
ExPASy Enzyme Link: ExPASy2.1.1.1
EC2PDB Enzyme Link: EC2PDB 2.1.1.1
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.1
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.1
IntEnz Enzyme Link: IntEnz 2.1.1.1
MEDLINE Enzyme Link: MEDLINE 2.1.1.1
MSA:

2.1.1.1;

Phylogenetic Tree:

2.1.1.1;

Uniprot:
M-CSA:
RHEA:23884 nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[n;H0;+0:6]:[*:7]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[n+;H0:6](:[*:7])-[CH3;+0:4]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Mouse nicotinamide N-methyltransferase gene: molecular cloning, structural characterization, and chromosomal localization.Yan L, Otterness DM, Kozak CA, Weinshilboum RM1998 Aug9726248
Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization.Aksoy S, Szumlanski CL, Weinshilboum RM1994 May 208182091