EC number:2.1.1.100

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.100
Description:Protein-S-isoprenylcysteine O-methyltransferase.
Alternative Name: Prenylcysteine carboxyl methyltransferase.
Prenylated protein carboxyl methyltransferase.
Isoprenylcysteine carboxylmethyltransferase.
Cath: 1.10.10.10; 3.30.1330.20; 3.30.1330.200; 3.40.50.180; 3.40.50.2300;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.100
BRENDA Enzyme Link: BRENDA 2.1.1.100
KEGG Enzyme Link: KEGG2.1.1.100
BioCyc Enzyme Link: BioCyc 2.1.1.100
ExPASy Enzyme Link: ExPASy2.1.1.100
EC2PDB Enzyme Link: EC2PDB 2.1.1.100
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.100
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.100
IntEnz Enzyme Link: IntEnz 2.1.1.100
MEDLINE Enzyme Link: MEDLINE 2.1.1.100

EC number:2.1.1.100

MSA:

2.1.1.100;
Phylogenetic Tree:

2.1.1.100;
Uniprot:
M-CSA:
RHEA:21672 [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.Clarke S, Vogel JP, Deschenes RJ, Stock J1988 Jul3290900
Enzymatic methylation of 23-29-kDa bovine retinal rod outer segment membrane proteins. Evidence for methyl ester formation at carboxyl-terminal cysteinyl residues.Ota IM, Clarke S1989 Aug 52753892
Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate.Stephenson RC, Clarke S1990 Sep 252398053