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2. Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

ID:

2.1.1.113

Description:

Site-specific DNA-methyltransferase (cytosine-N(4)-specific).

Alternative Name:

Restriction-modification system.
N(4)-cytosine-specific DNA methylase.
Modification methylase.

Prosite:

PDOC00088;

PDB:

PDB	Scop
1BOO	8019918; 8032298;

Cath:

3.40.50.150;

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PDB	Click once to unfold,double click to fold. 1BOO;

UniProtKB Enzyme Link:	UniProtKB 2.1.1.113
BRENDA Enzyme Link:	BRENDA 2.1.1.113
KEGG Enzyme Link:	KEGG2.1.1.113
BioCyc Enzyme Link:	BioCyc 2.1.1.113
ExPASy Enzyme Link:	ExPASy2.1.1.113
EC2PDB Enzyme Link:	EC2PDB 2.1.1.113
ExplorEnz Enzyme Link:	ExplorEnz 2.1.1.113
PRIAM enzyme-specific profiles Link:	PRIAM 2.1.1.113
IntEnz Enzyme Link:	IntEnz 2.1.1.113
MEDLINE Enzyme Link:	MEDLINE 2.1.1.113

RHEA:16857	a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[NH2;+0:2].[:3]-[S+;H0:4](-[:5])-[CH3;+0:6]>>[:1]-[NH;+0:2]-[CH3;+0:6].[:3]-[S;H0;+0:4]-[:5]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Structure and mechanism of multifunctional restriction endonucleases.	Yuan R	1981	6267988
Specificity of restriction endonucleases and DNA modification methyltransferases a review (Edition 3).	Kessler C, Manta V	1990 Aug 16	2172084
Restriction enzymes and their isoschizomers.	Roberts RJ	1990 Apr 25	2159140
Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases.	Klimasauskas S, Timinskas A, Menkevicius S, Butkienè D, Butkus V, Janulaitis A	1989 Dec 11	2690010
Identification of the CTAG-recognizing restriction-modification systems MthZI and MthFI from Methanobacterium thermoformicicum and characterization of the plasmid-encoded mthZIM gene.	Nölling J, de Vos WM	1992 Oct 11	1408820