EC number:2.1.1.122

Enzyme

Download
EC Tree
     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.122
Description:(S)-tetrahydroprotoberberine N-methyltransferase.
Alternative Name: Tetrahydroprotoberberine cis-N-methyltransferase.

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.122
BRENDA Enzyme Link: BRENDA 2.1.1.122
KEGG Enzyme Link: KEGG2.1.1.122
BioCyc Enzyme Link: BioCyc 2.1.1.122
ExPASy Enzyme Link: ExPASy2.1.1.122
EC2PDB Enzyme Link: EC2PDB 2.1.1.122
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.122
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.122
IntEnz Enzyme Link: IntEnz 2.1.1.122
MEDLINE Enzyme Link: MEDLINE 2.1.1.122

EC number:2.1.1.122

MSA:

2.1.1.122;
Phylogenetic Tree:

2.1.1.122;
Uniprot:
M-CSA:
RHEA:12805 (S)-canadine + S-adenosyl-L-methionine = (S)-N-methylcanadine + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[N;H0;+0:2](-[*:3])-[*:4].[*:5]-[S+;H0:6](-[*:7])-[CH3;+0:8]>>[*:1]-[N+;H0:2](-[*:3])(-[*:4])-[CH3;+0:8].[*:5]-[S;H0;+0:6]-[*:7]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Targeted metabolite and transcript profiling for elucidating enzyme function: isolation of novel N-methyltransferases from three benzylisoquinoline alkaloid-producing species.Liscombe DK, Ziegler J, Schmidt J, Ammer C, Facchini PJ2009 Nov19624470
Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy.Liscombe DK, Facchini PJ2007 May 1817389594