EC number:2.1.1.13

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.13
Description:Methionine synthase.
Alternative Name: Vitamin B12 methyltransferase.
Tetrahydropteroylglutamic methyltransferase.
Tetrahydropteroylglutamate methyltransferase.
Tetrahydrofolate methyltransferase.
N-methyltetrahydrofolate:L-homocysteine methyltransferase.
N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase.
N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase.
N(5)-methyltetrahydrofolate methyltransferase.
Methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase.
Methionine synthetase.
Methionine synthase (cobalamin-dependent).
Cobalamin-dependent methionine synthase.
B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase.
5-methyltetrahydrofolate--homocysteine transmethylase.
5-methyltetrahydrofolate--homocysteine S-methyltransferase.
Prosite: PDOC50972;
PDB:
PDBScop
4DJD 8045246; 8051753; 8051754; 8089862; 8089870; 8089871; 8089872; 8089873; 8051754; 8089873; 8031492; 8043870; 8031492; 8043870; 8045246; 8051753; 8089862; 8089870; 8089871; 8089872;
4DJF 8031492; 8043870; 8051754; 8089873; 8031492; 8043870; 8045246; 8051753; 8089862; 8089870; 8089871; 8089872; 8051754; 8089873; 8045246; 8051753; 8089862; 8089870; 8089871; 8089872;
4DJE 8031492; 8043870; 8045246; 8051753; 8089862; 8089870; 8089871; 8089872; 8051754; 8089873; 8045246; 8051753; 8089862; 8089870; 8089871; 8089872; 8031492; 8043870; 8051754; 8089873;
2OGY 8031492; 8043870; 8031492; 8043870;
2E7F 8031492; 8043870; 8031492; 8043870;
 » show all
Cath: 1.10.1240.10; 1.10.288.10; 3.20.20.20; 3.20.20.210; 3.20.20.330; 3.40.109.40; 3.40.50.720; 3.40.50.80; 3.40.640.10; 3.90.1150.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.13
BRENDA Enzyme Link: BRENDA 2.1.1.13
KEGG Enzyme Link: KEGG2.1.1.13
BioCyc Enzyme Link: BioCyc 2.1.1.13
ExPASy Enzyme Link: ExPASy2.1.1.13
EC2PDB Enzyme Link: EC2PDB 2.1.1.13
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.13
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.13
IntEnz Enzyme Link: IntEnz 2.1.1.13
MEDLINE Enzyme Link: MEDLINE 2.1.1.13

EC number:2.1.1.13

MSA:

2.1.1.13;
Phylogenetic Tree:

2.1.1.13;
Uniprot:
M-CSA:
RHEA:11172 (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
RULE(radius=1) [*:1]-[N;H0;+0:2](-[*:3])-[CH3;+0:4].[*:5]-[SH;+0:6]>>[*:1]-[NH;+0:2]-[*:3].[*:5]-[S;H0;+0:6]-[CH3;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Mutations in the B12-binding region of methionine synthase: how the protein controls methylcobalamin reactivity.Jarrett JT, Amaratunga M, Drennan CL, Scholten JD, Sands RH, Ludwig ML, Matthews RG1996 Feb 208652590
How a protein binds B12: A 3.0 A X-ray structure of B12-binding domains of methionine synthase.Drennan CL, Huang S, Drummond JT, Matthews RG, Lidwig ML1994 Dec 97992050
Cobalamin-dependent methionine synthase: the structure of a methylcobalamin-binding fragment and implications for other B12-dependent enzymes.Drennan CL, Matthews RG, Ludwig ML1994 Dec7712296
Cobalamin-dependent methionine synthase.Banerjee RV, Matthews RG1990 Mar2407589
Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML2002 Jan11731805
Protonation state of methyltetrahydrofolate in a binary complex with cobalamin-dependent methionine synthase.Smith AE, Matthews RG2000 Nov 1411076529
Interaction of flavodoxin with cobalamin-dependent methionine synthase.Hall DA, Jordan-Starck TC, Loo RO, Ludwig ML, Matthews RG2000 Sep 510978155