EC number:2.1.1.130

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.130
Description:Precorrin-2 C(20)-methyltransferase.
Alternative Name: S-adenosyl-L-methionine--precorrin-2 methyltransferase.
Precorrin-2 C20-methyltransferase.
Cath: 3.30.950.10; 3.40.1010.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.130
BRENDA Enzyme Link: BRENDA 2.1.1.130
KEGG Enzyme Link: KEGG2.1.1.130
BioCyc Enzyme Link: BioCyc 2.1.1.130
ExPASy Enzyme Link: ExPASy2.1.1.130
EC2PDB Enzyme Link: EC2PDB 2.1.1.130
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.130
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.130
IntEnz Enzyme Link: IntEnz 2.1.1.130
MEDLINE Enzyme Link: MEDLINE 2.1.1.130

EC number:2.1.1.130

MSA:

2.1.1.130;
Phylogenetic Tree:

2.1.1.130;
Uniprot:
M-CSA:
RHEA:16841 precorrin-2 + S-adenosyl-L-methionine = H(+) + precorrin-3A + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[NH;+0:2]-[C;H0;+0:3](-[*:4])=[CH;+0:5]-[C;H0;+0:6](-[*:7])=[N;H0;+0:8]-[*:9]=[CH;+0:10]-[*:11].[*:12]-[S+;H0:13](-[*:14])-[CH3;+0:15]>>[*:1]-[N;H0;+0:2]=[C;H0;+0:3](-[*:4])-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[NH;+0:8]-[*:9]=[C;H0;+0:10](-[*:11])-[CH3;+0:15].[*:12]-[S;H0;+0:13]-[*:14]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Overexpression in Escherichia coli of 12 vitamin B12 biosynthetic enzymes.Roessner CA, Spencer JB, Ozaki S, Min C, Atshaves BP, Nayar P, Anousis N, Stolowich NJ, Holderman MT, Scott AI1995 Apr7606163
Expression of 9 Salmonella typhimurium enzymes for cobinamide synthesis. Identification of the 11-methyl and 20-methyl transferases of corrin biosynthesis.Roessner CA, Warren MJ, Santander PJ, Atshaves BP, Ozaki S, Stolowich NJ, Iida K, Scott AI1992 Apr 131451790
Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans.Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F1993 Nov8226690