EC number:2.1.1.137

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.137
Description:Arsenite methyltransferase.
Alternative Name: S-adenosyl-L-methionine:methylarsonite As-methyltransferase.
S-adenosyl-L-methionine:arsenic(III) methyltransferase.
Methylarsonite methyltransferase.
Cath: 1.20.1050.10; 3.40.250.10; 3.40.30.10; 3.40.50.2300;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.137
BRENDA Enzyme Link: BRENDA 2.1.1.137
KEGG Enzyme Link: KEGG2.1.1.137
BioCyc Enzyme Link: BioCyc 2.1.1.137
ExPASy Enzyme Link: ExPASy2.1.1.137
EC2PDB Enzyme Link: EC2PDB 2.1.1.137
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.137
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.137
IntEnz Enzyme Link: IntEnz 2.1.1.137
MEDLINE Enzyme Link: MEDLINE 2.1.1.137

EC number:2.1.1.137

MSA:

2.1.1.137;
Phylogenetic Tree:

2.1.1.137;
Uniprot:
M-CSA:
RHEA:15293 arsenite + S-adenosyl-L-methionine = H(+) + methylarsonate + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[As;H0;+0:2](-[*:3])-[OH;+0:4].[*:5]-[S+;H0:6](-[*:7])-[CH3;+0:8]>>[*:1]-[As;H0;+0:2](-[*:3])(-[CH3;+0:8])=[O;H0;+0:4].[*:5]-[S;H0;+0:6]-[*:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver.Zakharyan R, Wu Y, Bogdan GM, Aposhian HV1995 Dec8605285
A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol.Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ2002 Mar 2911790780
Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase.Zakharyan RA, Aposhian HV1999 Dec10604879
Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes.Zakharyan RA, Ayala-Fierro F, Cullen WR, Carter DM, Aposhian HV1999 Jul 110387927
RHEA:11684 methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[As;H0;+0:2](-[*:3])-[OH;+0:4].[*:5]-[S+;H0:6](-[*:7])-[CH3;+0:8]>>[*:1]-[As;H0;+0:2](-[*:3])(-[CH3;+0:8])=[O;H0;+0:4].[*:5]-[S;H0;+0:6]-[*:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver.Zakharyan R, Wu Y, Bogdan GM, Aposhian HV1995 Dec8605285
A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol.Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ2002 Mar 2911790780
Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase.Zakharyan RA, Aposhian HV1999 Dec10604879
Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes.Zakharyan RA, Ayala-Fierro F, Cullen WR, Carter DM, Aposhian HV1999 Jul 110387927
Interactive Effects of N6AMT1 and As3MT in Arsenic Biomethylation.Zhang H, Ge Y, He P, Chen X, Carina A, Qiu Y, Aga DS, Ren X2015 Aug25997655
Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity.Ren X, Aleshin M, Jo WJ, Dills R, Kalman DA, Vulpe CD, Smith MT, Zhang L2011 Jun21193388