EC number:2.1.1.14
| ID: | 2.1.1.14 |
|---|---|
| Description: | 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. |
| Alternative Name: |
Tetrahydropteroylglutamate-homocysteine transmethylase. Methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase. Methionine synthase (cobalamin-independent). Homocysteine methylase. Cobalamin-independent methionine synthase. |
| Cath: | 1.10.1240.10; 1.10.288.10; 3.20.20.20; 3.20.20.210; 3.20.20.330; 3.40.109.40; 3.40.50.280; 3.10.196.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.14 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.14 |
| KEGG Enzyme Link: | KEGG2.1.1.14 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.14 |
| ExPASy Enzyme Link: | ExPASy2.1.1.14 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.14 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.14 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.14 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.14 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.14 |
| RHEA:45016 | 5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine = L-selenomethionine + tetrahydropteroyltri-L-glutamate |
| RULE(radius=1) | [*:1]-[N;H0;+0:2](-[*:3])-[CH3;+0:4].[*:5]-[SeH;+0:6]>>[*:1]-[NH;+0:2]-[*:3].[*:5]-[Se;H0;+0:6]-[CH3;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| L-Selenohomocysteine: one-step synthesis from L-selenomethionine and kinetic analysis as substrate for methionine synthases. | Zhou ZS, Smith AE, Matthews RG | 2000 Nov 6 | 11078203 |
| RHEA:21196 | 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate |
| RULE(radius=1) | [*:1]-[N;H0;+0:2](-[*:3])-[CH3;+0:4].[*:5]-[SH;+0:6]>>[*:1]-[NH;+0:2]-[*:3].[*:5]-[S;H0;+0:6]-[CH3;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cobalamin-independent methionine synthase from Escherichia coli: a zinc metalloenzyme. | González JC, Peariso K, Penner-Hahn JE, Matthews RG | 1996 Sep 24 | 8823155 |
| Vitamin-B12-independent methionine synthase from a higher plant (Catharanthus roseus). Molecular characterization, regulation, heterologous expression, and enzyme properties. | Eichel J, González JC, Hotze M, Matthews RG, Schröder J | 1995 Jun 15 | 7601135 |
| Transfer of the methyl group from N5-methyltetrahydrofolates to homocysteine in Escherichia coli. | Guest JR, Friedman S, Foster MA, Tejerina G, Woods DD | 1964 Sep | 5319972 |
| Purification and properties of 5-methyltetrahydropteroyltriglutamate-homocysteine transmethylase. | Whitfield CD, Steers EJ Jr, Weissbach H | 1970 Jan 25 | 4904482 |