EC number:2.1.1.151
| ID: | 2.1.1.151 |
|---|---|
| Description: | Cobalt-factor II C(20)-methyltransferase. |
| Alternative Name: |
Cobalt-precorrin-2 C(20)-methyltransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.151 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.151 |
| KEGG Enzyme Link: | KEGG2.1.1.151 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.151 |
| ExPASy Enzyme Link: | ExPASy2.1.1.151 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.151 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.151 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.151 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.151 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.151 |
EC number:2.1.1.151
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:17997 | Co-precorrin-2 + S-adenosyl-L-methionine = Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[*:3].[*:4]-[S+;H0:5](-[*:6])-[CH3;+0:7]>>[*:1]-[C;H0;+0:2](=[*:3])-[CH3;+0:7].[*:4]-[S;H0;+0:5]-[*:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Definition of the redox states of cobalt-precorrinoids: investigation of the substrate and redox specificity of CbiL from Salmonella typhimurium. | Spencer P, Stolowich NJ, Sumner LW, Scott AI | 1998 Oct 20 | 9778368 |
| Elucidation of substrate specificity in the cobalamin (vitamin B12) biosynthetic methyltransferases. Structure and function of the C20 methyltransferase (CbiL) from Methanothermobacter thermautotrophicus. | Frank S, Deery E, Brindley AA, Leech HK, Lawrence A, Heathcote P, Schubert HL, Brocklehurst K, Rigby SE, Warren MJ, Pickersgill RW | 2007 Aug 17 | 17567575 |
| Crystal structures of CbiL, a methyltransferase involved in anaerobic vitamin B biosynthesis, and CbiL in complex with S-adenosylhomocysteine--implications for the reaction mechanism. | Wada K, Harada J, Yaeda Y, Tamiaki H, Oh-Oka H, Fukuyama K | 2007 Jan | 17229157 |
| Anaerobic synthesis of vitamin B12: characterization of the early steps in the pathway. | Frank S, Brindley AA, Deery E, Heathcote P, Lawrence AD, Leech HK, Pickersgill RW, Warren MJ | 2005 Aug | 16042604 |
| Expression of 9 Salmonella typhimurium enzymes for cobinamide synthesis. Identification of the 11-methyl and 20-methyl transferases of corrin biosynthesis. | Roessner CA, Warren MJ, Santander PJ, Atshaves BP, Ozaki S, Stolowich NJ, Iida K, Scott AI | 1992 Apr 13 | 1451790 |