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2. Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

ID:

2.1.1.163

Description:

Demethylmenaquinone methyltransferase.

Alternative Name:

Demethylmenaquinone C-methylase.
2-heptaprenyl-1,4-naphthoquinone methyltransferase.
2-demethylmenaquinone methyltransferase.

Prosite:

PDOC00911;

PDB:

PDB	Scop
4OBX
4OBW

Cath:

3.40.50.150;

3D structure

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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

PDB	Click once to unfold,double click to fold. 4OBX; 4OBW;

References

External Links

UniProtKB Enzyme Link:	UniProtKB 2.1.1.163
BRENDA Enzyme Link:	BRENDA 2.1.1.163
KEGG Enzyme Link:	KEGG2.1.1.163
BioCyc Enzyme Link:	BioCyc 2.1.1.163
ExPASy Enzyme Link:	ExPASy2.1.1.163
EC2PDB Enzyme Link:	EC2PDB 2.1.1.163
ExplorEnz Enzyme Link:	ExplorEnz 2.1.1.163
PRIAM enzyme-specific profiles Link:	PRIAM 2.1.1.163
IntEnz Enzyme Link:	IntEnz 2.1.1.163
MEDLINE Enzyme Link:	MEDLINE 2.1.1.163

MSA:	2.1.1.163;
Phylogenetic Tree:	2.1.1.163;
Uniprot:
M-CSA:

RHEA:26462	6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine = 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[CH;+0:2]=[:3].[:4]-[S+;H0:5](-[:6])-[CH3;+0:7]>>[:1]-[C;H0;+0:2](=[:3])-[CH3;+0:7].[:4]-[S;H0;+0:5]-[:6]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

References

Title	Authors	Date	PubMed ID
An Escherichia coli mutant containing only demethylmenaquinone, but no menaquinone: effects on fumarate, dimethylsulfoxide, trimethylamine N-oxide and nitrate respiration.	Wissenbach U, Ternes D, Unden G	1992	1444716

RHEA:26466	a 2-demethylmenaquinone + S-adenosyl-L-methionine = a menaquinone + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[CH;+0:2]=[:3].[:4]-[S+;H0:5](-[:6])-[CH3;+0:7]>>[:1]-[C;H0;+0:2](=[:3])-[CH3;+0:7].[:4]-[S;H0;+0:5]-[:6]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

References

Title	Authors	Date	PubMed ID
A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene.	Lee PT, Hsu AY, Ha HT, Clarke CF	1997 Mar	9045837
An Escherichia coli mutant containing only demethylmenaquinone, but no menaquinone: effects on fumarate, dimethylsulfoxide, trimethylamine N-oxide and nitrate respiration.	Wissenbach U, Ternes D, Unden G	1992	1444716

RHEA:30063	2-demethylmenaquinol-8 + S-adenosyl-L-methionine = H(+) + menaquinol-8 + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[S+;H0:2](-[:3])-[CH3;+0:4].[:5]:[cH;+0:6]:[:7]>>[:1]-[S;H0;+0:2]-[:3].[:5]:[c;H0;+0:6](:[:7])-[CH3;+0:4]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

RHEA:33255	2-demethylmenaquinol-7 + S-adenosyl-L-methionine = H(+) + menaquinol-7 + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[S+;H0:2](-[:3])-[CH3;+0:4].[:5]:[cH;+0:6]:[:7]>>[:1]-[S;H0;+0:2]-[:3].[:5]:[c;H0;+0:6](:[:7])-[CH3;+0:4]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

RHEA:42640	a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[S+;H0:2](-[:3])-[CH3;+0:4].[:5]:[cH;+0:6]:[:7]>>[:1]-[S;H0;+0:2]-[:3].[:5]:[c;H0;+0:6](:[:7])-[CH3;+0:4]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

References

Title	Authors	Date	PubMed ID
Identification of a novel gene cluster participating in menaquinone (vitamin K2) biosynthesis. Cloning and sequence determination of the 2-heptaprenyl-1,4-naphthoquinone methyltransferase gene of Bacillus stearothermophilus.	Koike-Takeshita A, Koyama T, Ogura K	1997 May 9	9139683
A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene.	Lee PT, Hsu AY, Ha HT, Clarke CF	1997 Mar	9045837

RHEA:44776	2-demethylmenaquinol-6 + S-adenosyl-L-methionine = H(+) + menaquinol-6 + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[S+;H0:2](-[:3])-[CH3;+0:4].[:5]:[cH;+0:6]:[:7]>>[:1]-[S;H0;+0:2]-[:3].[:5]:[c;H0;+0:6](:[:7])-[CH3;+0:4]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

RHEA:44780	2-demethylmenaquinol-9 + S-adenosyl-L-methionine = H(+) + menaquinol-9 + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[S+;H0:2](-[:3])-[CH3;+0:4].[:5]:[cH;+0:6]:[:7]>>[:1]-[S;H0;+0:2]-[:3].[:5]:[c;H0;+0:6](:[:7])-[CH3;+0:4]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

RHEA:44784	2-demethylmenaquinol-10 + S-adenosyl-L-methionine = H(+) + menaquinol-10 + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[S+;H0:2](-[:3])-[CH3;+0:4].[:5]:[cH;+0:6]:[:7]>>[:1]-[S;H0;+0:2]-[:3].[:5]:[c;H0;+0:6](:[:7])-[CH3;+0:4]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

RHEA:44788	2-demethylmenaquinol-11 + S-adenosyl-L-methionine = H(+) + menaquinol-11 + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[S+;H0:2](-[:3])-[CH3;+0:4].[:5]:[cH;+0:6]:[:7]>>[:1]-[S;H0;+0:2]-[:3].[:5]:[c;H0;+0:6](:[:7])-[CH3;+0:4]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

RHEA:44792	2-demethylmenaquinol-12 + S-adenosyl-L-methionine = H(+) + menaquinol-12 + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[S+;H0:2](-[:3])-[CH3;+0:4].[:5]:[cH;+0:6]:[:7]>>[:1]-[S;H0;+0:2]-[:3].[:5]:[c;H0;+0:6](:[:7])-[CH3;+0:4]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

RHEA:44796	2-demethylmenaquinol-13 + S-adenosyl-L-methionine = H(+) + menaquinol-13 + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[S+;H0:2](-[:3])-[CH3;+0:4].[:5]:[cH;+0:6]:[:7]>>[:1]-[S;H0;+0:2]-[:3].[:5]:[c;H0;+0:6](:[:7])-[CH3;+0:4]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

EC number:2.1.1.163

Enzyme

3D structure

References

External Links

EC number:2.1.1.163

References

References

References

Reaction analysis:2.1.1.163