EC number:2.1.1.184
| ID: | 2.1.1.184 |
|---|---|
| Description: | 23S rRNA (adenine(2085)-N(6))-dimethyltransferase. |
| Cath: | 1.10.8.10; 1.10.8.100; 3.40.50.150; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.184 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.184 |
| KEGG Enzyme Link: | KEGG2.1.1.184 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.184 |
| ExPASy Enzyme Link: | ExPASy2.1.1.184 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.184 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.184 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.184 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.184 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.184 |
EC number:2.1.1.184
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:42784 | adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[*:3].[*:4]-[S+;H0:5](-[*:6])-[CH3;+0:7]>>[*:1]-[N;H0;+0:2](-[*:3])-[CH3;+0:7].[*:4]-[S;H0;+0:5]-[*:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria. | Bussiere DE, Muchmore SW, Dealwis CG, Schluckebier G, Nienaber VL, Edalji RP, Walter KA, Ladror US, Holzman TF, Abad-Zapatero C | 1998 May 19 | 9585521 |
| Substrate requirements for ErmC' methyltransferase activity. | Zhong P, Pratt SD, Edalji RP, Walter KA, Holzman TF, Shivakumar AG, Katz L | 1995 Aug | 7543473 |
| Mono- and dimethylating activities and kinetic studies of the ermC 23 S rRNA methyltransferase. | Denoya C, Dubnau D | 1989 Feb 15 | 2492520 |
| Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC' redefines the substrate-binding site and suggests a model for protein-RNA interactions. | Maravić G, Bujnicki JM, Feder M, Pongor S, Flögel M | 2003 Aug 15 | 12907737 |
| The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism. | Schluckebier G, Zhong P, Stewart KD, Kavanaugh TJ, Abad-Zapatero C | 1999 Jun 4 | 10366505 |