EC number:2.1.1.185
| ID: | 2.1.1.185 |
|---|---|
| Description: | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase. |
| Cath: | 3.30.1330.30; 3.40.1280.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.185 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.185 |
| KEGG Enzyme Link: | KEGG2.1.1.185 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.185 |
| ExPASy Enzyme Link: | ExPASy2.1.1.185 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.185 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.185 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.185 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.185 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.185 |
EC number:2.1.1.185
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:24140 | guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot. | Michel G, Sauvé V, Larocque R, Li Y, Matte A, Cygler M | 2002 Oct | 12377117 |
| The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli. | Lövgren JM, Wikström PM | 2001 Dec | 11698387 |