EC number:2.1.1.187

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.187
Description:23S rRNA (guanine(745)-N(1))-methyltransferase.
Alternative Name: Ribosomal RNA(m(1)G)-methylase.
23S rRNA m(1)G(745) methyltransferase.
Cath: 3.40.50.150;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.187
BRENDA Enzyme Link: BRENDA 2.1.1.187
KEGG Enzyme Link: KEGG2.1.1.187
BioCyc Enzyme Link: BioCyc 2.1.1.187
ExPASy Enzyme Link: ExPASy2.1.1.187
EC2PDB Enzyme Link: EC2PDB 2.1.1.187
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.187
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.187
IntEnz Enzyme Link: IntEnz 2.1.1.187
MEDLINE Enzyme Link: MEDLINE 2.1.1.187

EC number:2.1.1.187

MSA:

2.1.1.187;
Phylogenetic Tree:

2.1.1.187;
Uniprot:
M-CSA:
RHEA:42900 guanosine(745) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[nH;+0:6]:[*:7]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[n;H0;+0:6](:[*:7])-[CH3;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant.Gustafsson C, Persson BC1998 Jan9440525
Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase.Liu M, Novotny GW, Douthwaite S2004 Nov15388872