EC number:2.1.1.188

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.188
Description:23S rRNA (guanine(748)-N(1))-methyltransferase.
Alternative Name: Tylosin-resistance methyltransferase RlmA(II).
rRNA large subunit methyltransferase II.
23S rRNA m(1)G(748) methyltransferase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.188
BRENDA Enzyme Link: BRENDA 2.1.1.188
KEGG Enzyme Link: KEGG2.1.1.188
BioCyc Enzyme Link: BioCyc 2.1.1.188
ExPASy Enzyme Link: ExPASy2.1.1.188
EC2PDB Enzyme Link: EC2PDB 2.1.1.188
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.188
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.188
IntEnz Enzyme Link: IntEnz 2.1.1.188
MEDLINE Enzyme Link: MEDLINE 2.1.1.188

EC number:2.1.1.188

MSA:

2.1.1.188;
Phylogenetic Tree:

2.1.1.188;
Uniprot:
M-CSA:
RHEA:42904 guanosine(748) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[nH;+0:6]:[*:7]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[n;H0;+0:6](:[*:7])-[CH3;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748.Douthwaite S, Crain PF, Liu M, Poehlsgaard J2004 Apr 915046978
The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA.Liu M, Kirpekar F, Van Wezel GP, Douthwaite S2000 Aug10972803