EC number:2.1.1.2
| ID: | 2.1.1.2 |
|---|---|
| Description: | Guanidinoacetate N-methyltransferase. |
| Cath: | 3.40.50.150; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.2 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.2 |
| KEGG Enzyme Link: | KEGG2.1.1.2 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.2 |
| ExPASy Enzyme Link: | ExPASy2.1.1.2 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.2 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.2 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.2 |
| RHEA:10656 | guanidinoacetate + S-adenosyl-L-methionine = creatine + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[*:3].[*:4]-[S+;H0:5](-[*:6])-[CH3;+0:7]>>[*:1]-[N;H0;+0:2](-[*:3])-[CH3;+0:7].[*:4]-[S;H0;+0:5]-[*:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man. | Stöckler S, Isbrandt D, Hanefeld F, Schmidt B, von Figura K | 1996 May | 8651275 |
| Catalytic mechanism of guanidinoacetate methyltransferase: crystal structures of guanidinoacetate methyltransferase ternary complexes. | Komoto J, Yamada T, Takata Y, Konishi K, Ogawa H, Gomi T, Fujioka M, Takusagawa F | 2004 Nov 16 | 15533043 |
| Crystal structure of guanidinoacetate methyltransferase from rat liver: a model structure of protein arginine methyltransferase. | Komoto J, Huang Y, Takata Y, Yamada T, Konishi K, Ogawa H, Gomi T, Fujioka M, Takusagawa F | 2002 Jul 5 | 12079381 |