Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.20
Description:Glycine N-methyltransferase.
Alternative Name: Glycine methyltransferase.
Cath: 3.30.46.10; 3.40.50.150;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.20
BRENDA Enzyme Link: BRENDA 2.1.1.20
KEGG Enzyme Link: KEGG2.1.1.20
BioCyc Enzyme Link: BioCyc 2.1.1.20
ExPASy Enzyme Link: ExPASy2.1.1.20
EC2PDB Enzyme Link: EC2PDB 2.1.1.20
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.20
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.20
IntEnz Enzyme Link: IntEnz 2.1.1.20
MEDLINE Enzyme Link: MEDLINE 2.1.1.20
MSA:

2.1.1.20;

Phylogenetic Tree:

2.1.1.20;

Uniprot:
M-CSA:
RHEA:19937 glycine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sarcosine
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[NH;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Structure, function and physiological role of glycine N-methyltransferase.Ogawa H, Gomi T, Takusagawa F, Fujioka M1998 Jan9597750
Crystal structure of glycine N-methyltransferase from rat liver.Fu Z, Hu Y, Konishi K, Takata Y, Ogawa H, Gomi T, Fujioka M, Takusagawa F1996 Sep 178810903
Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes.Pakhomova S, Luka Z, Grohmann S, Wagner C, Newcomer ME2004 Nov 115340920
Catalytic mechanism of glycine N-methyltransferase.Takata Y, Huang Y, Komoto J, Yamada T, Konishi K, Ogawa H, Gomi T, Fujioka M, Takusagawa F2003 Jul 2212859184
A substrate switch: a new mode of regulation in the methionine metabolic pathway.Martinov MV, Vitvitsky VM, Mosharov EV, Banerjee R, Ataullakhanov FI2000 Jun 2110833353
Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.Huang Y, Komoto J, Konishi K, Takata Y, Ogawa H, Gomi T, Fujioka M, Takusagawa F2000 Apr 2110756111
Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica.Waditee R, Tanaka Y, Aoki K, Hibino T, Jikuya H, Takano J, Takabe T, Takabe T2003 Feb 1412466265
Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase.Nyyssölä A, Reinikainen T, Leisola M2001 May11319079
Extreme halophiles synthesize betaine from glycine by methylation.Nyyssola A, Kerovuo J, Kaukinen P, von Weymarn N, Reinikainen T2000 Jul 2110896953