EC number:2.1.1.200

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.200
Description:tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase.
Alternative Name: TrMet(Xm32).
Cath: 1.10.8.590; 3.40.1280.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.200
BRENDA Enzyme Link: BRENDA 2.1.1.200
KEGG Enzyme Link: KEGG2.1.1.200
BioCyc Enzyme Link: BioCyc 2.1.1.200
ExPASy Enzyme Link: ExPASy2.1.1.200
EC2PDB Enzyme Link: EC2PDB 2.1.1.200
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.200
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.200
IntEnz Enzyme Link: IntEnz 2.1.1.200
MEDLINE Enzyme Link: MEDLINE 2.1.1.200

EC number:2.1.1.200

MSA:

2.1.1.200;
Phylogenetic Tree:

2.1.1.200;
Uniprot:
M-CSA:
RHEA:42936 S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.Jaroensuk J, Atichartpongkul S, Chionh YH, Wong YH, Liew CW, McBee ME, Thongdee N, Prestwich EG, DeMott MS, Mongkolsuk S, Dedon PC, Lescar J, Fuangthong M2016 Dec 1527683218
The yfhQ gene of Escherichia coli encodes a tRNA:Cm32/Um32 methyltransferase.Purta E, van Vliet F, Tkaczuk KL, Dunin-Horkawicz S, Mori H, Droogmans L, Bujnicki JM2006 Jul 1816848900
RHEA:42932 cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.Jaroensuk J, Atichartpongkul S, Chionh YH, Wong YH, Liew CW, McBee ME, Thongdee N, Prestwich EG, DeMott MS, Mongkolsuk S, Dedon PC, Lescar J, Fuangthong M2016 Dec 1527683218
The yfhQ gene of Escherichia coli encodes a tRNA:Cm32/Um32 methyltransferase.Purta E, van Vliet F, Tkaczuk KL, Dunin-Horkawicz S, Mori H, Droogmans L, Bujnicki JM2006 Jul 1816848900