EC number:2.1.1.202
| ID: | 2.1.1.202 |
|---|---|
| Description: | Multisite-specific tRNA:(cytosine-C(5))-methyltransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.202 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.202 |
| KEGG Enzyme Link: | KEGG2.1.1.202 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.202 |
| ExPASy Enzyme Link: | ExPASy2.1.1.202 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.202 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.202 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.202 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.202 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.202 |
EC number:2.1.1.202
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:42940 | cytidine(34) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[cH;+0:6]:[*:7]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[c;H0;+0:6](:[*:7])-[CH3;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Pleiotropic effects of intron removal on base modification pattern of yeast tRNAPhe: an in vitro study. | Jiang HQ, Motorin Y, Jin YX, Grosjean H | 1997 Jul 15 | 9207014 |
| Effect of intron mutations on processing and function of Saccharomyces cerevisiae SUP53 tRNA in vitro and in vivo. | Strobel MC, Abelson J | 1986 Jul | 3537724 |
| Cysteine of sequence motif VI is essential for nucleophilic catalysis by yeast tRNA m5C methyltransferase. | Walbott H, Husson C, Auxilien S, Golinelli-Pimpaneau B | 2007 Jul | 17475914 |
| Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme. | Motorin Y, Grosjean H | 1999 Aug | 10445884 |
| RHEA:42944 | cytidine(40) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[cH;+0:6]:[*:7]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[c;H0;+0:6](:[*:7])-[CH3;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Pleiotropic effects of intron removal on base modification pattern of yeast tRNAPhe: an in vitro study. | Jiang HQ, Motorin Y, Jin YX, Grosjean H | 1997 Jul 15 | 9207014 |
| Effect of intron mutations on processing and function of Saccharomyces cerevisiae SUP53 tRNA in vitro and in vivo. | Strobel MC, Abelson J | 1986 Jul | 3537724 |
| Cysteine of sequence motif VI is essential for nucleophilic catalysis by yeast tRNA m5C methyltransferase. | Walbott H, Husson C, Auxilien S, Golinelli-Pimpaneau B | 2007 Jul | 17475914 |
| Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme. | Motorin Y, Grosjean H | 1999 Aug | 10445884 |
| RHEA:42948 | cytidine(48) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[cH;+0:6]:[*:7]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[c;H0;+0:6](:[*:7])-[CH3;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Pleiotropic effects of intron removal on base modification pattern of yeast tRNAPhe: an in vitro study. | Jiang HQ, Motorin Y, Jin YX, Grosjean H | 1997 Jul 15 | 9207014 |
| Effect of intron mutations on processing and function of Saccharomyces cerevisiae SUP53 tRNA in vitro and in vivo. | Strobel MC, Abelson J | 1986 Jul | 3537724 |
| Cysteine of sequence motif VI is essential for nucleophilic catalysis by yeast tRNA m5C methyltransferase. | Walbott H, Husson C, Auxilien S, Golinelli-Pimpaneau B | 2007 Jul | 17475914 |
| Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme. | Motorin Y, Grosjean H | 1999 Aug | 10445884 |
| RHEA:42952 | cytidine(49) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[cH;+0:6]:[*:7]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[c;H0;+0:6](:[*:7])-[CH3;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Pleiotropic effects of intron removal on base modification pattern of yeast tRNAPhe: an in vitro study. | Jiang HQ, Motorin Y, Jin YX, Grosjean H | 1997 Jul 15 | 9207014 |
| Effect of intron mutations on processing and function of Saccharomyces cerevisiae SUP53 tRNA in vitro and in vivo. | Strobel MC, Abelson J | 1986 Jul | 3537724 |
| Cysteine of sequence motif VI is essential for nucleophilic catalysis by yeast tRNA m5C methyltransferase. | Walbott H, Husson C, Auxilien S, Golinelli-Pimpaneau B | 2007 Jul | 17475914 |
| Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme. | Motorin Y, Grosjean H | 1999 Aug | 10445884 |