EC number:2.1.1.209

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.209
Description:23S rRNA (guanine(2535)-N(1))-methyltransferase.
Cath: 1.10.287.540; 3.30.1330.30; 3.40.1280.10; 3.40.50.150;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.209
BRENDA Enzyme Link: BRENDA 2.1.1.209
KEGG Enzyme Link: KEGG2.1.1.209
BioCyc Enzyme Link: BioCyc 2.1.1.209
ExPASy Enzyme Link: ExPASy2.1.1.209
EC2PDB Enzyme Link: EC2PDB 2.1.1.209
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.209
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.209
IntEnz Enzyme Link: IntEnz 2.1.1.209
MEDLINE Enzyme Link: MEDLINE 2.1.1.209

EC number:2.1.1.209

MSA:

2.1.1.209;
Phylogenetic Tree:

2.1.1.209;
Uniprot:
M-CSA:
RHEA:43096 guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[nH;+0:6]:[*:7]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[n;H0;+0:6](:[*:7])-[CH3;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose.Treede I, Jakobsen L, Kirpekar F, Vester B, Weitnauer G, Bechthold A, Douthwaite S2003 Jul12828631
Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes.Mosbacher TG, Bechthold A, Schulz GE2003 May 2312742024