EC number:2.1.1.213
| ID: | 2.1.1.213 |
|---|---|
| Description: | tRNA (guanine(10)-N(2))-dimethyltransferase. |
| Alternative Name: |
N(2),N(2)-dimethylguanosine tRNA methyltransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.213 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.213 |
| KEGG Enzyme Link: | KEGG2.1.1.213 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.213 |
| ExPASy Enzyme Link: | ExPASy2.1.1.213 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.213 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.213 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.213 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.213 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.213 |
EC number:2.1.1.213
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:43124 | guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6].[*:7]-[S+;H0:8](-[*:9])-[CH3;+0:10]>>[*:1]-[N;H0;+0:2](-[CH3;+0:10])-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5].[*:7]-[S;H0;+0:8]-[*:9] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA. | Purushothaman SK, Bujnicki JM, Grosjean H, Lapeyre B | 2005 Jun | 15899842 |
| N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota. | Armengaud J, Urbonavicius J, Fernandez B, Chaussinand G, Bujnicki JM, Grosjean H | 2004 Aug 27 | 15210688 |