EC number:2.1.1.215

Enzyme

Download
EC Tree
     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.215
Description:tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase.
Cath: 3.30.56.70; 3.40.50.150;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.215
BRENDA Enzyme Link: BRENDA 2.1.1.215
KEGG Enzyme Link: KEGG2.1.1.215
BioCyc Enzyme Link: BioCyc 2.1.1.215
ExPASy Enzyme Link: ExPASy2.1.1.215
EC2PDB Enzyme Link: EC2PDB 2.1.1.215
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.215
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.215
IntEnz Enzyme Link: IntEnz 2.1.1.215
MEDLINE Enzyme Link: MEDLINE 2.1.1.215

EC number:2.1.1.215

MSA:

2.1.1.215;
Phylogenetic Tree:

2.1.1.215;
Uniprot:
M-CSA:
RHEA:43136 guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6].[*:7]-[S+;H0:8](-[*:9])-[CH3;+0:10]>>[*:1]-[N;H0;+0:2](-[CH3;+0:10])-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5].[*:7]-[S;H0;+0:8]-[*:9]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Aquifex aeolicus tRNA (N2,N2-guanine)-dimethyltransferase (Trm1) catalyzes transfer of methyl groups not only to guanine 26 but also to guanine 27 in tRNA.Awai T, Kimura S, Tomikawa C, Ochi A, Ihsanawati, Bessho Y, Yokoyama S, Ohno S, Nishikawa K, Yokogawa T, Suzuki T, Hori H2009 Jul 3119491098