EC number:2.1.1.216

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.216
Description:tRNA (guanine(26)-N(2))-dimethyltransferase.
Alternative Name: tRNA (m(2)(2)G(26))dimethyltransferase.
Cath: 3.30.56.70; 3.40.50.150;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.216
BRENDA Enzyme Link: BRENDA 2.1.1.216
KEGG Enzyme Link: KEGG2.1.1.216
BioCyc Enzyme Link: BioCyc 2.1.1.216
ExPASy Enzyme Link: ExPASy2.1.1.216
EC2PDB Enzyme Link: EC2PDB 2.1.1.216
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.216
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.216
IntEnz Enzyme Link: IntEnz 2.1.1.216
MEDLINE Enzyme Link: MEDLINE 2.1.1.216

EC number:2.1.1.216

MSA:

2.1.1.216;
Phylogenetic Tree:

2.1.1.216;
Uniprot:
M-CSA:
RHEA:43140 guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6].[*:7]-[S+;H0:8](-[*:9])-[CH3;+0:10]>>[*:1]-[N;H0;+0:2](-[CH3;+0:10])-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5].[*:7]-[S;H0;+0:8]-[*:9]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The tRNA(guanine-26,N2-N2) methyltransferase (Trm1) from the hyperthermophilic archaeon Pyrococcus furiosus: cloning, sequencing of the gene and its expression in Escherichia coli.Constantinesco F, Benachenhou N, Motorin Y, Grosjean H1998 Aug 159685492
Characterisation and enzymatic properties of tRNA(guanine 26, N (2), N (2))-dimethyltransferase (Trm1p) from Pyrococcus furiosus.Constantinesco F, Motorin Y, Grosjean H1999 Aug 1310438627