EC number:2.1.1.221

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.221
Description:tRNA (guanine(9)-N(1))-methyltransferase.
Alternative Name: tRNA m(1)G(9)-methyltransferase.
tRNA m(1)G(9) MTase.
Cath: 3.40.1280.30;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.221
BRENDA Enzyme Link: BRENDA 2.1.1.221
KEGG Enzyme Link: KEGG2.1.1.221
BioCyc Enzyme Link: BioCyc 2.1.1.221
ExPASy Enzyme Link: ExPASy2.1.1.221
EC2PDB Enzyme Link: EC2PDB 2.1.1.221
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.221
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.221
IntEnz Enzyme Link: IntEnz 2.1.1.221
MEDLINE Enzyme Link: MEDLINE 2.1.1.221

EC number:2.1.1.221

MSA:

2.1.1.221;
Phylogenetic Tree:

2.1.1.221;
Uniprot:
M-CSA:
RHEA:43156 guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-dimethylguanosine(9) in tRNA + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[nH;+0:6]:[*:7]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[n;H0;+0:6](:[*:7])-[CH3;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA.Kempenaers M, Roovers M, Oudjama Y, Tkaczuk KL, Bujnicki JM, Droogmans L2010 Oct20525789
Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9.Jackman JE, Montange RK, Malik HS, Phizicky EM2003 May12702816