EC number:2.1.1.228
| ID: | 2.1.1.228 |
|---|---|
| Description: | tRNA (guanine(37)-N(1))-methyltransferase. |
| Alternative Name: |
tRNA-(N(1)G37) methyltransferase. tRNA (m(1)G(37)) methyltransferase. Transfer RNA (m(1)G(37)) methyltransferase. |
| Cath: | 1.10.1270.20; 3.30.300.110; 3.30.70.2580; 3.40.1280.10; 3.40.50.150; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.228 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.228 |
| KEGG Enzyme Link: | KEGG2.1.1.228 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.228 |
| ExPASy Enzyme Link: | ExPASy2.1.1.228 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.228 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.228 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.228 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.228 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.228 |
EC number:2.1.1.228
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:36899 | guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[nH;+0:6]:[*:7]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[n;H0;+0:6](:[*:7])-[CH3;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Evolution of tRNAPhe:imG2 methyltransferases involved in the biosynthesis of wyosine derivatives in Archaea. | Urbonavičius J, Rutkienė R, Lopato A, Tauraitė D, Stankevičiūtė J, Aučynaitė A, Kaliniene L, van Tilbeurgh H, Meškys R | 2016 Dec | 27852927 |
| Biosynthesis of wyosine derivatives in tRNA: an ancient and highly diverse pathway in Archaea. | de Crécy-Lagard V, Brochier-Armanet C, Urbonavicius J, Fernandez B, Phillips G, Lyons B, Noma A, Alvarez S, Droogmans L, Armengaud J, Grosjean H | 2010 Sep | 20382657 |
| Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase. | Lee C, Kramer G, Graham DE, Appling DR | 2007 Sep 21 | 17652090 |
| The substrate specificity of tRNA (m1G37) methyltransferase (TrmD) from Aquifex aeolicus. | Takeda H, Toyooka T, Ikeuchi Y, Yokobori S, Okadome K, Takano F, Oshima T, Suzuki T, Endo Y, Hori H | 2006 Dec | 17121543 |
| Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5. | Goto-Ito S, Ito T, Ishii R, Muto Y, Bessho Y, Yokoyama S | 2008 Sep | 18384044 |
| Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein. | Brulé H, Elliott M, Redlak M, Zehner ZE, Holmes WM | 2004 Jul 20 | 15248782 |