EC number:2.1.1.229
| ID: | 2.1.1.229 |
|---|---|
| Description: | tRNA (carboxymethyluridine(34)-5-O)-methyltransferase. |
| Alternative Name: |
tRNA methyltransferase 9. |
| Cath: | 3.30.70.330; 2.60.120.1520; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.229 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.229 |
| KEGG Enzyme Link: | KEGG2.1.1.229 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.229 |
| ExPASy Enzyme Link: | ExPASy2.1.1.229 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.229 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.229 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.229 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.229 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.229 |
EC number:2.1.1.229
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:43208 | carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. | Fu D, Brophy JA, Chan CT, Atmore KA, Begley U, Paules RS, Dedon PC, Begley TJ, Samson LD | 2010 May | 20308323 |
| Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding. | Songe-Møller L, van den Born E, Leihne V, Vågbø CB, Kristoffersen T, Krokan HE, Kirpekar F, Falnes PØ, Klungland A | 2010 Apr | 20123966 |
| Novel methyltransferase for modified uridine residues at the wobble position of tRNA. | Kalhor HR, Clarke S | 2003 Dec | 14645538 |