EC number:2.1.1.247

Enzyme

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EC Tree
     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.247
Description:methyltransferase.
Alternative Name: MT2-A.
Cath: 3.20.20.460;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.247
BRENDA Enzyme Link: BRENDA 2.1.1.247
KEGG Enzyme Link: KEGG2.1.1.247
BioCyc Enzyme Link: BioCyc 2.1.1.247
ExPASy Enzyme Link: ExPASy2.1.1.247
EC2PDB Enzyme Link: EC2PDB 2.1.1.247
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.247
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.247
IntEnz Enzyme Link: IntEnz 2.1.1.247
MEDLINE Enzyme Link: MEDLINE 2.1.1.247

EC number:2.1.1.247

MSA:

2.1.1.247;
Phylogenetic Tree:

2.1.1.247;
Uniprot:
M-CSA:
RHEA:45220 [methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M = [Co(I) trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M
RULE(radius=1) [*:1]-[SH;+0:2].[CH3;+0:3]-[Co+2;H0:4]>>[*:1]-[S;H0;+0:2]-[CH3;+0:3].[Co+;H0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri.Ferguson DJ Jr, Krzycki JA1997 Feb9006042
RHEA:45216 [methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M = [Co(I) dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M
RULE(radius=1) [*:1]-[SH;+0:2].[CH3;+0:3]-[Co+2;H0:4]>>[*:1]-[S;H0;+0:2]-[CH3;+0:3].[Co+;H0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri.Ferguson DJ Jr, Gorlatova N, Grahame DA, Krzycki JA2000 Sep 1510852929
RHEA:18773 [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M = [Co(I) methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M
RULE(radius=1) [*:1]-[SH;+0:2].[CH3;+0:3]-[Co+2;H0:4]>>[*:1]-[S;H0;+0:2]-[CH3;+0:3].[Co+;H0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine.Burke SA, Lo SL, Krzycki JA1998 Jul9642198
Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri.Ferguson DJ Jr, Krzycki JA1997 Feb9006042
Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression.LeClerc GM, Grahame DA1996 Aug 28702528
Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri.Ferguson DJ Jr, Gorlatova N, Grahame DA, Krzycki JA2000 Sep 1510852929