EC number:2.1.1.249

Enzyme

Download
EC Tree
     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.249
Description:[Dimethylamine--corrinoid protein] Co-methyltransferase.
Alternative Name: Dimethylamine methyltransferase.

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.249
BRENDA Enzyme Link: BRENDA 2.1.1.249
KEGG Enzyme Link: KEGG2.1.1.249
BioCyc Enzyme Link: BioCyc 2.1.1.249
ExPASy Enzyme Link: ExPASy2.1.1.249
EC2PDB Enzyme Link: EC2PDB 2.1.1.249
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.249
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.249
IntEnz Enzyme Link: IntEnz 2.1.1.249
MEDLINE Enzyme Link: MEDLINE 2.1.1.249

EC number:2.1.1.249

MSA:

2.1.1.249;
Phylogenetic Tree:

2.1.1.249;
Uniprot:
M-CSA:
RHEA:41175 [Co(I) dimethylamine-specific corrinoid protein] + dimethylamine + H(+) = [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine
RULE(radius=1) [*:1]-[NH;+0:2]-[CH3;+0:3].[Co+;H0:4].[H+;H0:5]>>[*:1]-[NH2;+0:2].[CH3;+0:3]-[Co+2;H0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri.Ferguson DJ Jr, Gorlatova N, Grahame DA, Krzycki JA2000 Sep 1510852929
Purification and characterization of dimethylamine:5-hydroxybenzimidazolyl-cobamide methyltransferase from Methanosarcina barkeri Fusaro.Wassenaar RW, Keltjens JT, van der Drift C, Vogels GD1998 May 19654067
Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases.Krzycki JA2004 Oct15450490