EC number:2.1.1.254

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.254
Description:Erythromycin 3''-O-methyltransferase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.254
BRENDA Enzyme Link: BRENDA 2.1.1.254
KEGG Enzyme Link: KEGG2.1.1.254
BioCyc Enzyme Link: BioCyc 2.1.1.254
ExPASy Enzyme Link: ExPASy2.1.1.254
EC2PDB Enzyme Link: EC2PDB 2.1.1.254
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.254
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.254
IntEnz Enzyme Link: IntEnz 2.1.1.254
MEDLINE Enzyme Link: MEDLINE 2.1.1.254

EC number:2.1.1.254

MSA:

2.1.1.254;
Phylogenetic Tree:

2.1.1.254;
Uniprot:
M-CSA:
RHEA:32651 erythromycin D + S-adenosyl-L-methionine = erythromycin B + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L1997 Oct9353926
Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli.Paulus TJ, Tuan JS, Luebke VE, Maine GT, DeWitt JP, Katz L1990 May2185226
RHEA:32647 erythromycin C + S-adenosyl-L-methionine = erythromycin A + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L1997 Oct9353926
Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli.Paulus TJ, Tuan JS, Luebke VE, Maine GT, DeWitt JP, Katz L1990 May2185226