EC number:2.1.1.257

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.257
Description:tRNA (pseudouridine(54)-N(1))-methyltransferase.
Alternative Name: M(1)-Psi methyltransferase.
Cath: 3.40.1280.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.257
BRENDA Enzyme Link: BRENDA 2.1.1.257
KEGG Enzyme Link: KEGG2.1.1.257
BioCyc Enzyme Link: BioCyc 2.1.1.257
ExPASy Enzyme Link: ExPASy2.1.1.257
EC2PDB Enzyme Link: EC2PDB 2.1.1.257
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.257
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.257
IntEnz Enzyme Link: IntEnz 2.1.1.257
MEDLINE Enzyme Link: MEDLINE 2.1.1.257

EC number:2.1.1.257

MSA:

2.1.1.257;
Phylogenetic Tree:

2.1.1.257;
Uniprot:
M-CSA:
RHEA:55292 pseudouridine(54) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[nH;+0:6]:[*:7]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[n;H0;+0:6](:[*:7])-[CH3;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs.Wurm JP, Griese M, Bahr U, Held M, Heckel A, Karas M, Soppa J, Wöhnert J2012 Mar22274954
The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at position 54 of tRNA.Chatterjee K, Blaby IK, Thiaville PC, Majumder M, Grosjean H, Yuan YA, Gupta R, de Crécy-Lagard V2012 Mar22274953
Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase.Chen HY, Yuan YA2010 Dec21098051