EC number:2.1.1.28
| ID: | 2.1.1.28 | ||
|---|---|---|---|
| Description: | Phenylethanolamine N-methyltransferase. | ||
| Alternative Name: |
Noradrenaline N-methyltransferase. | ||
| Prosite: | PDOC00844; | ||
| PDB: |
|
||
| Cath: | 3.40.50.150; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.28 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.28 |
| KEGG Enzyme Link: | KEGG2.1.1.28 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.28 |
| ExPASy Enzyme Link: | ExPASy2.1.1.28 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.28 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.28 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.28 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.28 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.28 |
| RHEA:25269 | (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[NH;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and properties of bovine phenylethanolamine N-methyltransferase. | Connett RJ, Kirshner N | 1970 Jan 25 | 5412063 |
| QM/MM studies on the catalytic mechanism of phenylethanolamine N-methyltransferase. | Hou QQ, Wang JH, Gao J, Liu YJ, Liu CB | 2012 Apr | 22326747 |
| Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis. | Gee CL, Tyndall JD, Grunewald GL, Wu Q, McLeish MJ, Martin JL | 2005 Dec 27 | 16363801 |
| RHEA:12176 | phenylethanolamine + S-adenosyl-L-methionine = H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[NH;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and properties of bovine phenylethanolamine N-methyltransferase. | Connett RJ, Kirshner N | 1970 Jan 25 | 5412063 |
| QM/MM studies on the catalytic mechanism of phenylethanolamine N-methyltransferase. | Hou QQ, Wang JH, Gao J, Liu YJ, Liu CB | 2012 Apr | 22326747 |
| Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis. | Gee CL, Tyndall JD, Grunewald GL, Wu Q, McLeish MJ, Martin JL | 2005 Dec 27 | 16363801 |