EC number:2.1.1.284

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.284
Description:8-demethylnovobiocic acid C(8)-methyltransferase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.284
BRENDA Enzyme Link: BRENDA 2.1.1.284
KEGG Enzyme Link: KEGG2.1.1.284
BioCyc Enzyme Link: BioCyc 2.1.1.284
ExPASy Enzyme Link: ExPASy2.1.1.284
EC2PDB Enzyme Link: EC2PDB 2.1.1.284
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.284
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.284
IntEnz Enzyme Link: IntEnz 2.1.1.284
MEDLINE Enzyme Link: MEDLINE 2.1.1.284

EC number:2.1.1.284

MSA:

2.1.1.284;
Phylogenetic Tree:

2.1.1.284;
Uniprot:
M-CSA:
RHEA:36651 8-desmethylnovobiocic acid + S-adenosyl-L-methionine = H(+) + novobiocic acid + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[cH;+0:6]:[*:7]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[c;H0;+0:6](:[*:7])-[CH3;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis.Pacholec M, Tao J, Walsh CT2005 Nov 1516274243