EC number:2.1.1.296
| ID: | 2.1.1.296 |
|---|---|
| Description: | Methyltransferase cap2. |
| Alternative Name: |
mRNA (nucleoside-2'-O)-methyltransferase. Cap2-MTase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.296 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.296 |
| KEGG Enzyme Link: | KEGG2.1.1.296 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.296 |
| ExPASy Enzyme Link: | ExPASy2.1.1.296 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.296 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.296 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.296 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.296 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.296 |
EC number:2.1.1.296
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:53044 | a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] + S-adenosyl-L-methionine = a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA] + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| 2'-O-methylation of position 2 of the trypanosome spliced leader cap 4 is mediated by a 48 kDa protein related to vaccinia virus VP39. | Arhin GK, Ullu E, Tschudi C | 2006 May | 16516986 |
| 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. | Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM | 2011 Jun | 21310715 |