EC number:2.1.1.297
| ID: | 2.1.1.297 |
|---|---|
| Description: | Peptide chain release factor N(5)-glutamine methyltransferase. |
| Alternative Name: |
N(5)-glutamine S-adenosyl-L-methionine dependent methyltransferase. N(5)-glutamine MTase. |
| Cath: | 1.10.8.10; 3.40.50.150; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.297 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.297 |
| KEGG Enzyme Link: | KEGG2.1.1.297 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.297 |
| ExPASy Enzyme Link: | ExPASy2.1.1.297 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.297 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.297 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.297 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.297 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.297 |
EC number:2.1.1.297
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:42896 | L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[NH;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural characterization and comparative phylogenetic analysis of Escherichia coli HemK, a protein (N5)-glutamine methyltransferase. | Yang Z, Shipman L, Zhang M, Anton BP, Roberts RJ, Cheng X | 2004 Jul 16 | 15223314 |
| X-ray crystallographic studies of HemK from Thermotoga maritima, an N5-glutamine methyltransferase. | Yoon HJ, Kang KY, Ahn HJ, Shim SM, Ha JY, Lee SK, Mikami B, Suh SW | 2003 Oct 31 | 14651272 |
| Structures along the catalytic pathway of PrmC/HemK, an N5-glutamine AdoMet-dependent methyltransferase. | Schubert HL, Phillips JD, Hill CP | 2003 May 20 | 12741815 |
| The hemK gene in Escherichia coli encodes the N(5)-glutamine methyltransferase that modifies peptide release factors. | Heurgué-Hamard V, Champ S, Engström A, Ehrenberg M, Buckingham RH | 2002 Feb 15 | 11847124 |