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2. Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

ID:	2.1.1.299
Description:	Protein N-terminal monomethyltransferase.
Alternative Name:	N-terminal monomethylase.

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UniProtKB Enzyme Link:	UniProtKB 2.1.1.299
BRENDA Enzyme Link:	BRENDA 2.1.1.299
KEGG Enzyme Link:	KEGG2.1.1.299
BioCyc Enzyme Link:	BioCyc 2.1.1.299
ExPASy Enzyme Link:	ExPASy2.1.1.299
EC2PDB Enzyme Link:	EC2PDB 2.1.1.299
ExplorEnz Enzyme Link:	ExplorEnz 2.1.1.299
PRIAM enzyme-specific profiles Link:	PRIAM 2.1.1.299
IntEnz Enzyme Link:	IntEnz 2.1.1.299
MEDLINE Enzyme Link:	MEDLINE 2.1.1.299

RHEA:54104	N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[NH2;+0:2].[:3]-[S+;H0:4](-[:5])-[CH3;+0:6]>>[:1]-[NH;+0:2]-[CH3;+0:6].[:3]-[S;H0;+0:4]-[:5]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Molecular basis for histone N-terminal methylation by NRMT1.	Wu R, Yue Y, Zheng X, Li H	2015 Nov 15	26543159
NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.	Petkowski JJ, Bonsignore LA, Tooley JG, Wilkey DW, Merchant ML, Macara IG, Schaner Tooley CE	2013 Dec 15	24090352
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.	Tooley CE, Petkowski JJ, Muratore-Schroeder TL, Balsbaugh JL, Shabanowitz J, Sabat M, Minor W, Hunt DF, Macara IG	2010 Aug 26	20668449

RHEA:54100	N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[NH;+0:2]-[:3].[:4]-[S+;H0:5](-[:6])-[CH3;+0:7]>>[:1]-[N;H0;+0:2](-[:3])-[CH3;+0:7].[:4]-[S;H0;+0:5]-[:6]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.	Petkowski JJ, Bonsignore LA, Tooley JG, Wilkey DW, Merchant ML, Macara IG, Schaner Tooley CE	2013 Dec 15	24090352

RHEA:54096	N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[NH2;+0:2].[:3]-[S+;H0:4](-[:5])-[CH3;+0:6]>>[:1]-[NH;+0:2]-[CH3;+0:6].[:3]-[S;H0;+0:4]-[:5]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Molecular basis for histone N-terminal methylation by NRMT1.	Wu R, Yue Y, Zheng X, Li H	2015 Nov 15	26543159
NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.	Petkowski JJ, Bonsignore LA, Tooley JG, Wilkey DW, Merchant ML, Macara IG, Schaner Tooley CE	2013 Dec 15	24090352
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.	Tooley CE, Petkowski JJ, Muratore-Schroeder TL, Balsbaugh JL, Shabanowitz J, Sabat M, Minor W, Hunt DF, Macara IG	2010 Aug 26	20668449