EC number:2.1.1.303

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.303
Description:2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase.
Alternative Name: Neocarzinostatin O-methyltransferase.
Cath: 1.10.10.10; 1.10.287.1350; 3.40.50.150;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.303
BRENDA Enzyme Link: BRENDA 2.1.1.303
KEGG Enzyme Link: KEGG2.1.1.303
BioCyc Enzyme Link: BioCyc 2.1.1.303
ExPASy Enzyme Link: ExPASy2.1.1.303
EC2PDB Enzyme Link: EC2PDB 2.1.1.303
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.303
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.303
IntEnz Enzyme Link: IntEnz 2.1.1.303
MEDLINE Enzyme Link: MEDLINE 2.1.1.303

EC number:2.1.1.303

MSA:

2.1.1.303;
Phylogenetic Tree:

2.1.1.303;
Uniprot:
M-CSA:
RHEA:41536 2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.Cooke HA, Guenther EL, Luo Y, Shen B, Bruner SD2009 Oct 1319702337
Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.Luo Y, Lin S, Zhang J, Cooke HA, Bruner SD, Shen B2008 May 2318387946