EC number:2.1.1.314
| ID: | 2.1.1.314 |
|---|---|
| Description: | Diphthine methyl ester synthase. |
| Alternative Name: |
Diphthine methyltransferase. |
| Cath: | 3.30.950.10; 3.40.1010.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.314 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.314 |
| KEGG Enzyme Link: | KEGG2.1.1.314 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.314 |
| ExPASy Enzyme Link: | ExPASy2.1.1.314 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.314 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.314 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.314 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.314 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.314 |
EC number:2.1.1.314
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:42652 | 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]-[S+;H0:6](-[*:7])-[CH3;+0:8].[*:9]-[S+;H0:10](-[*:11])-[CH3;+0:12].[*:13]-[S+;H0:14](-[*:15])-[CH3;+0:16].([*:17]1:[*:18]:[n;H0;+0:19]:[*:20]:[nH;+0:21]:1.[NH2;+0:22]-[*:23]-[*:24]-[OH;+0:25])>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]-[S;H0;+0:6]-[*:7].[*:9]-[S;H0;+0:10]-[*:11].[*:13]-[S;H0;+0:14]-[*:15].([*:17]1:[*:18]:[nH;+0:19]:[*:20]:[n;H0;+0:21]:1.[CH3;+0:8]-[N+;H0:22](-[CH3;+0:12])(-[CH3;+0:16])-[*:23]-[*:24]-[O;H0;+0:25]-[CH3;+0:4]) |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The post-translational trimethylation of diphthamide studied in vitro. | Moehring JM, Moehring TJ | 1988 Mar 15 | 3346227 |
| Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis. | Lin Z, Su X, Chen W, Ci B, Zhang S, Lin H | 2014 Apr 30 | 24739148 |
| Biosynthesis of diphthamide in Saccharomyces cerevisiae. Partial purification and characterization of a specific S-adenosylmethionine:elongation factor 2 methyltransferase. | Chen JY, Bodley JW | 1988 Aug 25 | 3042777 |
| Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. | Liu S, Milne GT, Kuremsky JG, Fink GR, Leppla SH | 2004 Nov | 15485916 |