EC number:2.1.1.316

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.316
Description:Mitomycin 6-O-methyltransferase.
Alternative Name: Mitomycin 7-O-methyltransferase.
Cath: 1.10.10.10; 3.40.50.150;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.316
BRENDA Enzyme Link: BRENDA 2.1.1.316
KEGG Enzyme Link: KEGG2.1.1.316
BioCyc Enzyme Link: BioCyc 2.1.1.316
ExPASy Enzyme Link: ExPASy2.1.1.316
EC2PDB Enzyme Link: EC2PDB 2.1.1.316
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.316
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.316
IntEnz Enzyme Link: IntEnz 2.1.1.316
MEDLINE Enzyme Link: MEDLINE 2.1.1.316

EC number:2.1.1.316

MSA:

2.1.1.316;
Phylogenetic Tree:

2.1.1.316;
Uniprot:
M-CSA:
RHEA:45104 6-demethylmitomycin A + S-adenosyl-L-methionine = mitomycin A + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Structural characterization of the mitomycin 7-O-methyltransferase.Singh S, Chang A, Goff RD, Bingman CA, Grüschow S, Sherman DH, Phillips GN Jr, Thorson JS2011 Jul21538548
Hydroxyquinone O-methylation in mitomycin biosynthesis.Grüschow S, Chang LC, Mao Y, Sherman DH2007 May 2317461583
RHEA:45100 6-demethylmitomycin B + S-adenosyl-L-methionine = mitomycin B + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Structural characterization of the mitomycin 7-O-methyltransferase.Singh S, Chang A, Goff RD, Bingman CA, Grüschow S, Sherman DH, Phillips GN Jr, Thorson JS2011 Jul21538548
Hydroxyquinone O-methylation in mitomycin biosynthesis.Grüschow S, Chang LC, Mao Y, Sherman DH2007 May 2317461583