EC number:2.1.1.336

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.336
Description:Norbelladine O-methyltransferase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.336
BRENDA Enzyme Link: BRENDA 2.1.1.336
KEGG Enzyme Link: KEGG2.1.1.336
BioCyc Enzyme Link: BioCyc 2.1.1.336
ExPASy Enzyme Link: ExPASy2.1.1.336
EC2PDB Enzyme Link: EC2PDB 2.1.1.336
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.336
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.336
IntEnz Enzyme Link: IntEnz 2.1.1.336
MEDLINE Enzyme Link: MEDLINE 2.1.1.336

EC number:2.1.1.336

MSA:

2.1.1.336;
Phylogenetic Tree:

2.1.1.336;
Uniprot:
M-CSA:
RHEA:51268 norbelladine + S-adenosyl-L-methionine = 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Cloning and characterization of a norbelladine 4'-O-methyltransferase involved in the biosynthesis of the Alzheimer's drug galanthamine in Narcissus sp. aff. pseudonarcissus.Kilgore MB, Augustin MM, Starks CM, O'Neil-Johnson M, May GD, Crow JA, Kutchan TM201425061748
ALKALOIDS AND PLANT METABOLISM. VI. O-METHYLATION IN VITRO OF NORBELLADINE, A PRECURSOR OF AMARYLLIDACEAE ALKALOIDS.MANN JD, FALES HM, MUDD SH1963 Nov14109227