EC number:2.1.1.341

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.341
Description:Vanillate/3-O-methylgallate O-demethylase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.341
BRENDA Enzyme Link: BRENDA 2.1.1.341
KEGG Enzyme Link: KEGG2.1.1.341
BioCyc Enzyme Link: BioCyc 2.1.1.341
ExPASy Enzyme Link: ExPASy2.1.1.341
EC2PDB Enzyme Link: EC2PDB 2.1.1.341
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.341
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.341
IntEnz Enzyme Link: IntEnz 2.1.1.341
MEDLINE Enzyme Link: MEDLINE 2.1.1.341

EC number:2.1.1.341

MSA:

2.1.1.341;
Phylogenetic Tree:

2.1.1.341;
Uniprot:
M-CSA:
RHEA:52280 (6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate
RULE(radius=1) [*:1]-[NH;+0:2]-[*:3].[*:4]-[O;H0;+0:5]-[CH3;+0:6]>>[*:1]-[N;H0;+0:2](-[*:3])-[CH3;+0:6].[*:4]-[OH;+0:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A tetrahydrofolate-dependent O-demethylase, LigM, is crucial for catabolism of vanillate and syringate in Sphingomonas paucimobilis SYK-6.Abe T, Masai E, Miyauchi K, Katayama Y, Fukuda M2005 Mar15743951
The crystal structure of a new O-demethylase from Sphingobium sp. strain SYK-6.Harada A, Kamimura N, Takeuchi K, Yu HY, Masai E, Senda T2017 Jun28429420
Structure of aryl <i>O</i>-demethylase offers molecular insight into a catalytic tyrosine-dependent mechanism.Kohler AC, Mills MJL, Adams PD, Simmons BA, Sale KL2017 Apr 1828373573
RHEA:52276 (6S)-5,6,7,8-tetrahydrofolate + 4-hydroxy-3-methoxybenzoate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate
RULE(radius=1) [*:1]-[NH;+0:2]-[*:3].[*:4]-[O;H0;+0:5]-[CH3;+0:6]>>[*:1]-[N;H0;+0:2](-[*:3])-[CH3;+0:6].[*:4]-[OH;+0:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A tetrahydrofolate-dependent O-demethylase, LigM, is crucial for catabolism of vanillate and syringate in Sphingomonas paucimobilis SYK-6.Abe T, Masai E, Miyauchi K, Katayama Y, Fukuda M2005 Mar15743951
The crystal structure of a new O-demethylase from Sphingobium sp. strain SYK-6.Harada A, Kamimura N, Takeuchi K, Yu HY, Masai E, Senda T2017 Jun28429420
Structure of aryl <i>O</i>-demethylase offers molecular insight into a catalytic tyrosine-dependent mechanism.Kohler AC, Mills MJL, Adams PD, Simmons BA, Sale KL2017 Apr 1828373573