EC number:2.1.1.343

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.343
Description:8-amino-8-demethylriboflavin N,N-dimethyltransferase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.343
BRENDA Enzyme Link: BRENDA 2.1.1.343
KEGG Enzyme Link: KEGG2.1.1.343
BioCyc Enzyme Link: BioCyc 2.1.1.343
ExPASy Enzyme Link: ExPASy2.1.1.343
EC2PDB Enzyme Link: EC2PDB 2.1.1.343
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.343
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.343
IntEnz Enzyme Link: IntEnz 2.1.1.343
MEDLINE Enzyme Link: MEDLINE 2.1.1.343

EC number:2.1.1.343

MSA:

2.1.1.343;
Phylogenetic Tree:

2.1.1.343;
Uniprot:
M-CSA:
RHEA:51944 8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine = 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6].[*:7]-[S+;H0:8](-[*:9])-[CH3;+0:10]>>[*:1]-[N;H0;+0:2](-[CH3;+0:10])-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5].[*:7]-[S;H0;+0:8]-[*:9]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-d-riboflavin to the antibiotic roseoflavin.Tongsook C, Uhl MK, Jankowitsch F, Mack M, Gruber K, Macheroux P2016 Apr26913589
A novel N,N-8-amino-8-demethyl-D-riboflavin Dimethyltransferase (RosA) catalyzing the two terminal steps of roseoflavin biosynthesis in Streptomyces davawensis.Jankowitsch F, Kühm C, Kellner R, Kalinowski J, Pelzer S, Macheroux P, Mack M2011 Nov 421911488