EC number:2.1.1.348

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.348
Description:mRNA m(6)A methyltransferase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.348
BRENDA Enzyme Link: BRENDA 2.1.1.348
KEGG Enzyme Link: KEGG2.1.1.348
BioCyc Enzyme Link: BioCyc 2.1.1.348
ExPASy Enzyme Link: ExPASy2.1.1.348
EC2PDB Enzyme Link: EC2PDB 2.1.1.348
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.348
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.348
IntEnz Enzyme Link: IntEnz 2.1.1.348
MEDLINE Enzyme Link: MEDLINE 2.1.1.348

EC number:2.1.1.348

MSA:

2.1.1.348;
Phylogenetic Tree:

2.1.1.348;
Uniprot:
M-CSA:
RHEA:55584 adenosine in mRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[NH;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Human m<sup>6</sup>A writers: Two subunits, 2 roles.Wang X, Huang J, Zou T, Yin P2017 Mar 428121234
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C2014 Feb24316715