EC number:2.1.1.35
| ID: | 2.1.1.35 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Description: | tRNA (uracil(54)-C(5))-methyltransferase. | ||||||||||||||||||||||||
| Alternative Name: |
tRNA:m(5)U(54)-methyltransferase. tRNA(uracil-54,C(5))-methyltransferase. tRNA(m(5)U(54))methyltransferase. tRNA uracil(54) 5-methyltransferase. tRNA uracil 5-methyltransferase. Transfer RNA uracil(54) methylase. Transfer RNA uracil(54) 5-methyltransferase. Transfer RNA uracil methylase. Transfer RNA uracil 5-methyltransferase. RUMT. Ribothymidyl synthase. M5U-methyltransferase. M(5)U(54)-methyltransferase. 5-methyluridine(54) tRNA methyltransferase. | ||||||||||||||||||||||||
| Prosite: | PDOC00945; | ||||||||||||||||||||||||
| PDB: |
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| Cath: | 3.40.1350.30; 3.50.50.60; 2.40.50.140; 3.40.50.150; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.35 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.35 |
| KEGG Enzyme Link: | KEGG2.1.1.35 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.35 |
| ExPASy Enzyme Link: | ExPASy2.1.1.35 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.35 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.35 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.35 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.35 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.35 |
| RHEA:42712 | S-adenosyl-L-methionine + uridine(54) in tRNA = 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[cH;+0:6]:[*:7]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[c;H0;+0:6](:[*:7])-[CH3;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymatic mechanism of tRNA (m5U54)methyltransferase. | Kealey JT, Gu X, Santi DV | 1994 | 7748948 |
| Isolation and chracterization of m5U-methyltransferase from Escherichia coli. | Greenberg R, Dudock B | 1980 Sep 10 | 6997293 |