EC number:2.1.1.4
| ID: | 2.1.1.4 |
|---|---|
| Description: | Acetylserotonin O-methyltransferase. |
| Alternative Name: |
Hydroxyindole O-methyltransferase. |
| Cath: | 1.10.10.10; 3.40.630.30; 3.40.50.150; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.4 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.4 |
| KEGG Enzyme Link: | KEGG2.1.1.4 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.4 |
| ExPASy Enzyme Link: | ExPASy2.1.1.4 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.4 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.4 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.4 |
| RHEA:15573 | N-acetylserotonin + S-adenosyl-L-methionine = H(+) + melatonin + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters. | Rodriguez IR, Mazuruk K, Schoen TJ, Chader GJ | 1994 Dec 16 | 7989373 |
| Hydroxyindole-O-methyltransferase activity in the pineal gland of the muskox (Ovibos moschatus). | Tedesco SC, Morton DJ, Reiter RJ | 1994 Apr | 7932034 |
| Hydroxyindole O-methyltransferase. | Sugden D, Ceña V, Klein DC | 1987 | 3298987 |
| Some properties of pineal gland hydroxyindole-O-methyltransferase from black rhinoceros (Diceros bicornis). | Morton DJ, Kock N | 1990 | 2338611 |
| Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway. | Botros HG, Legrand P, Pagan C, Bondet V, Weber P, Ben-Abdallah M, Lemière N, Huguet G, Bellalou J, Maronde E, Beguin P, Haouz A, Shepard W, Bourgeron T | 2013 Jan | 22775292 |