EC number:2.1.1.41
| ID: | 2.1.1.41 |
|---|---|
| Description: | Sterol 24-C-methyltransferase. |
| Alternative Name: |
Zymosterol-24-methyltransferase. SMT1. S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase. S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase. Phytosterol methyltransferase. Delta(24)-sterol methyltransferase. Delta(24)-methyltransferase. 24-sterol C-methyltransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.41 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.41 |
| KEGG Enzyme Link: | KEGG2.1.1.41 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.41 |
| ExPASy Enzyme Link: | ExPASy2.1.1.41 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.41 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.41 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.41 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.41 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.41 |
| RHEA:21128 | 5alpha-cholesta-8,24-dien-3beta-ol + S-adenosyl-L-methionine = 24-methylene-5alpha-cholest-8-en-3beta-ol + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]-[S+;H0:7](-[*:8])-[CH3;+0:9]>>[*:1]-[C;H0;+0:2](=[CH2;+0:9])-[CH;+0:3](-[*:4])-[*:5].[*:6]-[S;H0;+0:7]-[*:8] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Two families of sterol methyltransferases are involved in the first and the second methylation steps of plant sterol biosynthesis. | Bouvier-Navé P, Husselstein T, Benveniste P | 1998 Aug 15 | 9746350 |
| Overexpression, purification, and stereochemical studies of the recombinant (S)-adenosyl-L-methionine: delta 24(25)- to delta 24(28)-sterol methyl transferase enzyme from Saccharomyces cerevisiae. | Nes WD, McCourt BS, Zhou WX, Ma J, Marshall JA, Peek LA, Brennan M | 1998 May 15 | 9606964 |
| Stereochemistry of yeast delta 24-sterol methyl transferase. | Acuna-Johnson AP, Oehlschlager AC, Pierce AM, Pierce HD Jr, Czyzewska EK | 1997 May | 9208094 |
| Substrate-based inhibitors of the (S)-adenosyl-L-methionine:delta24(25)- to delta24(28)-sterol methyl transferase from Saccharomyces cerevisiae. | Nes WD, Guo D, Zhou W | 1997 Jun 1 | 9185615 |
| Mechanism and structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase from Saccharomyces cerevisiae. | Venkatramesh M, Guo DA, Jia Z, Nes WD | 1996 Feb 16 | 8597586 |
| Mechanism and inhibition of delta 24-sterol methyltransferase from Candida albicans and Candida tropicalis. | Ator MA, Schmidt SJ, Adams JL, Dolle RE | 1989 Dec 12 | 2692713 |
| Structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase. | Nes WD, Janssen GG, Bergenstrahle A | 1991 Aug 15 | 1869550 |
| Sterol methyl transferase: enzymology and inhibition. | Nes WD | 2000 Dec 15 | 11111078 |
| Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition. | Mangla AT, Nes WD | 2000 May | 10882005 |