EC number:2.1.1.43
| ID: | 2.1.1.43 |
|---|---|
| Description: | Histone-lysine N-methyltransferase. |
| Alternative Name: |
Protein-lysine N-methyltransferase. Protein methyltransferase II. Protein methylase III. Protein methylase 3. |
| Cath: | 1.10.10.1700; 1.10.1740.10; 1.10.1740.100; 1.10.260.170; 1.10.260.60; 1.10.30.10; 1.10.8.850; 1.20.5.4240; 3.30.160.60; 3.30.40.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.43 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.43 |
| KEGG Enzyme Link: | KEGG2.1.1.43 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.43 |
| ExPASy Enzyme Link: | ExPASy2.1.1.43 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.43 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.43 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.43 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.43 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.43 |
| RHEA:10024 | L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[NH;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Solubilization and partial purification of protein methylase 3 from calf thymus nuclei. | Paik WK, Kim S | 1970 Nov 25 | 5484460 |
| Partial purification and characterization of a protein lysine methyltransferase from plasmodia of Physarum polycephalum. | Venkatesan M, McManus IR | 1979 Nov 27 | 391266 |
| Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation. | Wang L, Li L, Zhang H, Luo X, Dai J, Zhou S, Gu J, Zhu J, Atadja P, Lu C, Li E, Zhao K | 2011 Nov 4 | 21880715 |
| The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation. | Qiao Q, Li Y, Chen Z, Wang M, Reinberg D, Xu RM | 2011 Mar 11 | 21196496 |
| Structural biology of human H3K9 methyltransferases. | Wu H, Min J, Lunin VV, Antoshenko T, Dombrovski L, Zeng H, Allali-Hassani A, Campagna-Slater V, Vedadi M, Arrowsmith CH, Plotnikov AN, Schapira M | 2010 Jan 11 | 20084102 |
| Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks. | Southall SM, Wong PS, Odho Z, Roe SM, Wilson JR | 2009 Jan 30 | 19187761 |
| Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation. | Edmunds JW, Mahadevan LC, Clayton AL | 2008 Jan 23 | 18157086 |
| PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. | Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K | 2007 Jul 13 | 17500065 |
| Identification of the MLL2 complex as a coactivator for estrogen receptor alpha. | Mo R, Rao SM, Zhu YJ | 2006 Jun 9 | 16603732 |
| Structural basis for the methylation site specificity of SET7/9. | Couture JF, Collazo E, Hauk G, Trievel RC | 2006 Feb | 16415881 |
| The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair. | Lee SH, Oshige M, Durant ST, Rasila KK, Williamson EA, Ramsey H, Kwan L, Nickoloff JA, Hromas R | 2005 Dec 13 | 16332963 |
| Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. | Tachibana M, Ueda J, Fukuda M, Takeda N, Ohta T, Iwanari H, Sakihama T, Kodama T, Hamakubo T, Shinkai Y | 2005 Apr 1 | 15774718 |
| ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3. | Byrd KN, Shearn A | 2003 Sep 30 | 13679578 |
| ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. | Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E | 2002 Nov | 12453419 |
| Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. | Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, Pirrotta V | 2002 Oct 18 | 12408863 |
| Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. | Fang J, Feng Q, Ketel CS, Wang H, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Simon JA, Zhang Y | 2002 Jul 9 | 12121615 |
| PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. | Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D | 2002 Jun | 12086618 |
| A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. | Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y | 2002 May 10 | 12004135 |
| Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. | Tachibana M, Sugimoto K, Fukushima T, Shinkai Y | 2001 Jul 6 | 11316813 |
| Regulation of chromatin structure by site-specific histone H3 methyltransferases. | Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T | 2000 Aug 10 | 10949293 |