EC number:2.1.1.49
| ID: | 2.1.1.49 |
|---|---|
| Description: | Amine N-methyltransferase. |
| Alternative Name: |
Tryptamine N-methyltransferase. Nicotine N-methyltransferase. Arylamine N-methyltransferase. |
| Cath: | 3.40.50.150; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.49 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.49 |
| KEGG Enzyme Link: | KEGG2.1.1.49 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.49 |
| ExPASy Enzyme Link: | ExPASy2.1.1.49 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.49 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.49 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.49 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.49 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.49 |
| RHEA:53928 | a tertiary amine + S-adenosyl-L-methionine = a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[N;H0;+0:2](-[*:3])-[*:4].[*:5]-[S+;H0:6](-[*:7])-[CH3;+0:8]>>[*:1]-[N+;H0:2](-[*:3])(-[*:4])-[CH3;+0:8].[*:5]-[S;H0;+0:6]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| S-adenosyl-L-methionine:thioether S-methyltransferase, a new enzyme in sulfur and selenium metabolism. | Mozier NM, McConnell KP, Hoffman JL | 1988 Apr 5 | 3350800 |
| Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases. | Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB | 1988 May 1 | 3377829 |
| RHEA:53924 | a secondary amine + S-adenosyl-L-methionine = a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[*:3].[*:4]-[S+;H0:5](-[*:6])-[CH3;+0:7]>>[*:1]-[N;H0;+0:2](-[*:3])-[CH3;+0:7].[*:4]-[S;H0;+0:5]-[*:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| S-adenosyl-L-methionine:thioether S-methyltransferase, a new enzyme in sulfur and selenium metabolism. | Mozier NM, McConnell KP, Hoffman JL | 1988 Apr 5 | 3350800 |
| Amine N-methyltransferases from rabbit liver. | Ansher SS, Jakoby WB | 1986 Mar 25 | 3949799 |
| Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases. | Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB | 1988 May 1 | 3377829 |
| RHEA:23136 | a primary amine + S-adenosyl-L-methionine = a methylated primary amine + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[NH;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization. | Thompson MA, Moon E, Kim UJ, Xu J, Siciliano MJ, Weinshilboum RM | 1999 Nov 1 | 10552930 |
| Amine N-methyltransferases from rabbit liver. | Ansher SS, Jakoby WB | 1986 Mar 25 | 3949799 |
| Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases. | Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB | 1988 May 1 | 3377829 |