EC number:2.1.1.57
| ID: | 2.1.1.57 |
|---|---|
| Description: | Methyltransferase cap1. |
| Alternative Name: |
mRNA (nucleoside-2'-O)-methyltransferase. Cap1-MTase. |
| Cath: | 1.10.10.930; 1.10.260.90; 1.10.8.970; 1.20.1280.260; 3.30.387.10; 3.30.67.10; 3.30.70.2840; 2.40.10.10; 2.40.10.120; 3.40.50.12760; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.57 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.57 |
| KEGG Enzyme Link: | KEGG2.1.1.57 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.57 |
| ExPASy Enzyme Link: | ExPASy2.1.1.57 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.57 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.57 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.57 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.57 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.57 |
| RHEA:19617 | a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] + S-adenosyl-L-methionine = a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA] + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Synthesis of mRNA guanylyltransferase and mRNA methyltransferases in cells infected with vaccinia virus. | Boone RF, Ensinger MJ, Moss B | 1977 Feb | 833934 |
| mRNA(nucleoside-2'-)-methyltransferase from vaccinia virus. Characteristics and substrate specificity. | Barbosa E, Moss B | 1978 Nov 10 | 701282 |
| mRNA(nucleoside-2'-)-methyltransferase from vaccinia virus. Purification and physical properties. | Barbosa E, Moss B | 1978 Nov 10 | 701281 |
| 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. | Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM | 2011 Jun | 21310715 |
| The 2'-O-ribose methyltransferase for cap 1 of spliced leader RNA and U1 small nuclear RNA in Trypanosoma brucei. | Zamudio JR, Mittra B, Foldynová-Trantírková S, Zeiner GM, Lukes J, Bujnicki JM, Sturm NR, Campbell DA | 2007 Sep | 17606627 |
| Autographa californica nucleopolyhedrovirus orf69 encodes an RNA cap (nucleoside-2'-O)-methyltransferase. | Wu X, Guarino LA | 2003 Mar | 12610118 |
| Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates. | Groner Y, Gilboa E, Aviv H | 1978 Mar 21 | 629955 |
| Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus. | Ensinger MJ, Martin SA, Paoletti E, Moss B | 1975 Jul | 1058472 |