EC number:2.1.1.61
| ID: | 2.1.1.61 |
|---|---|
| Description: | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase. |
| Cath: | 3.30.9.10; 3.40.50.620; 3.50.50.60; 2.30.30.280; 2.40.30.10; 3.40.50.150; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.61 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.61 |
| KEGG Enzyme Link: | KEGG2.1.1.61 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.61 |
| ExPASy Enzyme Link: | ExPASy2.1.1.61 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.61 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.61 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.61 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.61 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.61 |
| RHEA:19569 | 5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[NH;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biosynthesis of 5-methylaminomethyl-2-thiouridylate. I. Isolation of a new tRNA-methylase specific for 5-methylaminomethyl-2-thiouridylate. | Taya Y, Nishimura S | 1973 Apr 16 | 4703553 |
| Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC. | Kim J, Almo SC | 2013 Apr 24 | 23617613 |
| Identification of a bifunctional enzyme MnmC involved in the biosynthesis of a hypermodified uridine in the wobble position of tRNA. | Bujnicki JM, Oudjama Y, Roovers M, Owczarek S, Caillet J, Droogmans L | 2004 Aug | 15247431 |