EC number:2.1.1.62

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.62
Description:mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase.
Prosite: PDOC51143;
PDB:
PDBScop
5TEY 8046758; 8090782; 8046757; 8090781;
5L6E 8046758; 8090782; 8046757; 8090781;
5L6D 8046758; 8090782; 8046757; 8090781;
5K7M 8046758; 8090782; 8046757; 8090781;
5IL2 8046758; 8090782; 8046757; 8090781;
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3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.62
BRENDA Enzyme Link: BRENDA 2.1.1.62
KEGG Enzyme Link: KEGG2.1.1.62
BioCyc Enzyme Link: BioCyc 2.1.1.62
ExPASy Enzyme Link: ExPASy2.1.1.62
EC2PDB Enzyme Link: EC2PDB 2.1.1.62
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.62
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.62
IntEnz Enzyme Link: IntEnz 2.1.1.62
MEDLINE Enzyme Link: MEDLINE 2.1.1.62

EC number:2.1.1.62

MSA:

2.1.1.62;
Phylogenetic Tree:

2.1.1.62;
Uniprot:
M-CSA:
RHEA:22744 a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine 5'-phosphate)-[mRNA] + S-adenosyl-L-methionine = a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(N(7),2'-O-dimethyladenosine 5'-phosphate)-[mRNA] + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[NH;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase.Bokar JA, Shambaugh ME, Polayes D, Matera AG, Rottman FM1997 Nov9409616
HeLa cell RNA (2'-O-methyladenosine-N6-)-methyltransferase specific for the capped 5'-end of messenger RNA.Keith JM, Ensinger MJ, Moss B1978 Jul 25670176