EC number:2.1.1.64
| ID: | 2.1.1.64 |
|---|---|
| Description: | 3-demethylubiquinol 3-O-methyltransferase. |
| Alternative Name: |
5-demethylubiquinone-9 methyltransferase. 3-demethylubiquinone-9 3-methyltransferase. methyltransferase. 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone |
| Cath: | 3.40.50.150; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.64 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.64 |
| KEGG Enzyme Link: | KEGG2.1.1.64 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.64 |
| ExPASy Enzyme Link: | ExPASy2.1.1.64 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.64 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.64 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.64 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.64 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.64 |
| RHEA:17049 | 3-demethylubiquinol-9 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-9 |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| 5-demethylubiquinone-9-methyltransferase from rat liver mitochondria. Characterization, localization, and solubilization. | Houser RM, Olson RE | 1977 Jun 25 | 863914 |
| RHEA:28679 | 3-demethylubiquinol-8 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-8 |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Ubiquinone biosynthesis in microorganisms. | Meganathan R | 2001 Sep 25 | 11583838 |
| Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis. | Jonassen T, Clarke CF | 2000 Apr 28 | 10777520 |
| RHEA:44380 | a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Endogenous synthesis of coenzyme Q in eukaryotes. | Tran UC, Clarke CF | 2007 Jun | 17482885 |
| Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis. | Poon WW, Barkovich RJ, Hsu AY, Frankel A, Lee PT, Shepherd JN, Myles DC, Clarke CF | 1999 Jul 30 | 10419476 |
| RHEA:44400 | 3-demethylubiquinol-6 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-6 |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Regulation of coenzyme Q biosynthesis in yeast: a new complex in the block. | González-Mariscal I, García-Testón E, Padilla S, Martín-Montalvo A, Pomares-Viciana T, Vazquez-Fonseca L, Gandolfo-Domínguez P, Santos-Ocaña C | 2014 Feb | 24470391 |
| RHEA:44404 | 3-demethylubiquinol-7 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-7 |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
| RHEA:44412 | 3-demethylubiquinol-10 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-10 |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis. | Jonassen T, Clarke CF | 2000 Apr 28 | 10777520 |